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John C. Reilly Eli Sisters Joaquin Phoenix Charlie Sisters Jake Gyllenhaal John Morris Riz Ahmed Hermann Kermit Warm Rebecca Root Mayfield Allison Tolman Girl Mayfield Saloon Rutger Hauer The Commodore Carol Kane Mrs. Sisters Richard Brake Rex Hugo Dillon Dr. Crane Lexie Benbow-Hart Dr. Crane’s Daughter Diego Llano American River Indian Patrice Cossoneau Blount Zac Abbott Blount Guy Dying Trevor Allan Davies Golden Pearl Valet Jóhannes Haukur Jóhannesson Head Trapper Aidan O'Hare Horse Dealer American River Eric Colvin Horse Dealer Relay 2 Jochen Hägele Horse Dealer Town 3 Sean Duggan Jacksonville House Keeper Nick Cornwall Man Encampment Attacker #1 Duncan Lacroix Man Encampment Attacker #2 Jean-Marc Bellu Man Encampment Attacker #3 Raymond Waring Mayfield Bartender Frédéric Siuen Pacific Chinese Dad Prospector Kelda Holmes Poor Woman Commodore Andrew Litvack Prospector Creed Bratton Quarrel Saloon Guy Town 2 David Gasman Relay Owner Philip Rosch Storekeeper Pioneer Town 2 Ian Reddington The Father Lenuta Bala Woman with the Bortsch Aldo Maland Young Eli Sisters Theo Exarchopoulos Young Charlie Sisters
Oregon, 1851. Hermann Kermit Warm, a chemist and aspiring gold prospector, keeps a profitable secret that the Commodore wants to know, so he sends the Sisters brothers, two notorious assassins, to capture him on his way to California.
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